Lewis County Sheriff's Office responded to a head-on collision on US route 33 west near Pickle St. on Thursday, according to a news release from the Sheriff's Office.
Marcella Jamison, 56, was traveling west on Rt. 33 in a Pontiac Sunfire when it crossed the center line into the east bound lane.
Jamison's vehicle then struck a dodge neon operated by Henry Jenkins, 75, who was heading east on Rt. 33.
Lou Ann Jenkins, 56, the passenger in the dodge neon, sustained serious injuries and was dead at the scene, deputies said.
Both drivers were transported to Stonewall Jackson Memorial hospital and later transported to Ruby Memorial Hospital, according to the news release.
Deputies said the accident in still under investigation.