The Barbour County Sheriff's Department said a man may have suffered a fatal heart attack while driving.
It happened Wednesday morning on Route 57 near Shale Road.
Sheriff John Hawkins said Dean Weaver was at the wheel when he suffered what is believed to be a heart attack.
The car went off the road into a ditch.
Weaver's wife Karen survived the crash.
The sheriff's department is waiting for a report from the state medical examiner's office.