Firefighters responded to a house fire on Fairchance Road in Monongalia County just after noon on Tuesday.
The Brookhaven Volunteer Fire Department said the residents weren't home at the time of the fire and that the house is a total loss.
Fire departments from Cheat Lake, Star City, Granville, Point Marion, and Brookhaven responded to the scene. Monongalia County EMS also responded.
Fairchance Road (Route 857) was closed in both directions in the area of Sands Springs Road earlier Tuesday. According to MECCA 911, both lanes have since reopened.
The State Fire Marshal is investigating.